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为比较重组乙型肝炎(HB)疫苗和血源性HB疫苗的效果,作者选择日本冲绳幼儿园(至少有1例HBeAg携带者)的0～5岁儿童分别使用了此两种疫苗。重组HB疫苗(5μg)由酵母表达的抗原制备,118名(平均年龄为2.9岁)的儿童接种了重组疫苗;243名儿童接种了血源性疫苗(10μg),均按0、1、6月程序接种3剂。用放射免疫试验(RIA)检测所有血清标本的HBsAg、抗-HBs和-HBc,
To compare the efficacy of recombinant hepatitis B (HB) and blood-borne HB vaccines, the authors selected the two vaccines for children aged 0-5 years who were in Okinawa kindergarten (at least 1 HBeAg carrier) in Japan. Recombinant HB vaccine (5 μg) was prepared from yeast expressed antigens and 118 (mean age 2.9 years) children were vaccinated with the recombinant vaccine; 243 children were vaccinated with a blood-borne vaccine (10 μg), all at 0, 1, 6 months Program inoculation 3 doses. All serum samples were tested for HBsAg, anti-HBs and -HBc by radioimmunoassay (RIA)