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目的探讨丙种球蛋白应用于小儿全身炎症反应综合征的临床疗效。方法选择2006年以来笔者所在科收治的1～3岁全身炎症反应综合征患儿100例,均分为两组,对照组采用一般抗感染、对症支持治疗,治疗组在对照组治疗方案基础上加用人血丙种球蛋白静脉滴注,剂量为400 mg/kg。结果丙种球蛋白治疗后,取得了显著的疗效,与对照组相比差异具有统计学意义(P<0.05),且在体温及白细胞恢复正常所需时间、治愈出院时间上进行比较,治疗组均短于对照组(P<0.05),多脏器功能衰竭的发生率、全身炎症反应综合征的病死率均低于对照组(P<0.05)。结论丙种球蛋白治疗小儿全身炎症反应综合征安全、有效。
Objective To investigate the clinical efficacy of gamma globulin in children with systemic inflammatory response syndrome. Methods A total of 100 children aged 1-3 years old with systemic inflammatory response syndrome admitted to our department since 2006 were divided into two groups. The control group was generally anti-infective and symptomatic and supportive. The treatment group was based on the control group Plus intravenous infusion of human gamma globulin, a dose of 400 mg / kg. The results of gamma globulin after treatment, and achieved significant results, compared with the control group, the difference was statistically significant (P <0.05), and in the body temperature and the time required to return to normal, cured discharge time were compared, the treatment group (P <0.05). The incidence of multiple organ failure and systemic inflammatory response syndrome were lower than the control group (P <0.05). Conclusion Gamma globulin is safe and effective in the treatment of pediatric systemic inflammatory response syndrome.