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将甘草次酸25毫克注射于体重140-180克的大鼠,能引起明显的水和钠储留.此作用比1毫克的去氧皮盾酮醋酸酯(DOCA)作用稍强。5毫克的醛固酮拮抗剂SC-9420(spironolactone)可明显拮抗25毫克甘草次酸和1毫克DOCA的水和钠储留作用,但拮抗DOCA的作用更强.△~6-6-甲基皮质酮醋酸酯系一种有明显抗炎和利尿作用的甾体,该药能明显拮抗DOCA的水和钠储留作用,并促进钾的排泄,但对甘草次酸的作用无明显影响.此外,甘草次酸对戊巴比妥钠引起的小鼠睡眠时间无任何明显影响.以上结果指出,甘草次酸对电解质和水分代谢的作用与DOC十分相似.关于甘草次酸对电解质和水分代谢的作用机制存在两种看法,有些作者认为,甘草次酸能抑制体内皮质激素(包括DOC)的代谢性失活,血液中皮质激素浓度相应地升高,结果出现激素样作用;另一些人则认为,甘革次酸可直接作用于賢脏,起DOC样作用.本文强果支持后一种看法.
Injection of 25 mg glycyrrhetinic acid into rats weighing 140-180 g resulted in significant water and sodium retention, which was slightly stronger than 1 mg of deoxypernardivrel acetate (DOCA). 5 mg of aldosterone antagonist SC-9420 (spironolactone) significantly antagonized the water and sodium retention of 25 mg of glycyrrhetinic acid and 1 mg of DOCA, but antagonized the action of DOCA even more. Acetate is a steroid with obvious anti-inflammatory and diuretic effects. It can obviously antagonize the water and sodium retention of DOCA and promote the excretion of potassium, but has no obvious effect on glycyrrhetinic acid. In addition, Sodic acid on pentobarbital sodium-induced mice sleep time without any significant effect.The above results indicate that the effect of glycyrrhetinic acid on electrolytes and water metabolism and DOC are very similar on glycyrrhetinic acid on electrolyte and water metabolism mechanism There are two views, some authors believe that glycyrrhetinic acid can inhibit the metabolic inactivation of corticosteroids (including DOC), the corresponding increase in blood levels of corticosteroids, the results appear to be hormone-like effect; while others think that Gan Grapefruit acid can act directly on the Yin dirty, play the role of DOC-like. This strong fruit to support the latter view.