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托品酰胺(Tropicamide化学名N-乙基N-吡啶-4-甲基托品酰胺)是一种散瞳作用快速,散大瞳孔后恢复时间短,可使睫状肌麻痹的抗胆碱药,目前英、美、日三国药典中均有收载,我室干1982年2月合成成功。合成托品酰胺的方法较多,经过实践我们认为,以皮考林为原料,先制成其氮氧化物,然后经重排、水解等步骤,最终制得托品酰胺的方法是可行的。具体化学反应如下。方法与步骤一、4-皮考林氮氧化物Ⅱ的制备:
Tropicamide (Tropicamide chemical name N-ethyl N-pyridine-4-methyl ethanolamide) is a mydriatic rapid, wide pupil recovery time is short, the cycloplegic anticholinergic drugs, the current British The United States, Japan and the United States are contained in the pharmacopoeia, my room dry in 1982 February synthesis success. There are many ways to synthesize tropicamide. In practice, we think that it is feasible to make picolimine as the raw material and make its oxynitride first, and then rearrange and hydrolyze it to finally produce the tropicamide. The specific chemical reaction is as follows. Methods and steps A, 4-Picolin forest nitrogen oxide Ⅱ Preparation: