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在去缓冲神经大鼠观察莫索尼定对延髓腹外侧头端区（ＲＶＬＭ）神经元自发电活动的影响．向颈总动脉内注射莫索尼定２，１０，５０μｇ·ｋｇ－１后，同步记录神经元放电图，血压及心率．结果显示，莫索尼定剂量依赖性地降低ＲＶＬＭ神经元放电率，血压和心率．莫索尼定１０，５０μｇ·ｋｇ－１使放电率分别减少２３％和４１％．动脉注射选择性Ｉ１－咪唑啉受体阻断剂依法克生１０μｇ·ｋｇ－１，可完全拮抗莫索尼定１０μｇ·ｋｇ－１的作用．结果提示，莫索尼定通过激动延髓腹外侧头端区神经元上的Ｉ１－咪唑啉受体，抑制其自发放电活动．
To observe the effect of Moxonidine on spontaneous activity of rostral ventrolateral medulial region (RVLM) neurons in denervated rats. After the injection of Moxonidine 2,10,50 μg · kg-1 into the common carotid artery, the neuron discharge graph, blood pressure and heart rate were recorded simultaneously. The results showed that Moxonidine dose-dependently reduced the rate of RVLM neuron discharge, blood pressure and heart rate. Moxonidine 10,50μg · kg-1 reduced the discharge rate by 23% and 41% respectively. Arterial injection of a selective I1-imidazoline receptor blocker 10g · kg-1 according to the law gram, can completely antagonize the effect of moxonidine 10μg · kg-1. The results suggest that Moxonidine can inhibit its spontaneous discharge activity by activating I1-imidazoline receptors on the neurons in the rostral ventrolateral medulla of the rostral ventrolateral medulla.