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目的分析多发性骨髓瘤(MM)患者血清镁离子(Mg2+)水平与早期肾功能损害及自身终末免疫效应下降的相关性因素。方法选取MM患者57例,采集性别、年龄、血清Mg2+、尿比重和血清补体C3水平等数据,后三者做正态性检验;利用方差分析考察性别、年龄对后三者的混杂影响情况;在符合直线相关条件下,用SAS 8.1统计软件做出血清Mg2+分别与尿比重及血清补体C3水平的直线相关关系、相关性的强弱程度,选取具有典型代表性的20个数值试用Excel绘制散点图并试拟合出趋势直线。结果高血清Mg2+水平(≥1.1 mmol/L)患者尿比重较低;低血清Mg2+水平(<0.8 mmol/L)患者血清补体C3水平较低,且明显低于正常水平。结论高血清Mg2+水平患者可能易早期出现肾功能不全,低血清Mg2+水平患者可能免疫力较低,更易发生感染。
Objective To analyze the correlation between the level of serum magnesium (Mg2 +) in patients with multiple myeloma (MM) and the decline of early renal dysfunction and autoimmune terminal immune response. Methods Fifty-seven MM patients were selected. Data of gender, age, serum Mg2 +, urinary specific gravity and serum C3 level were collected and tested for normality. An analysis of variance was used to investigate the effects of gender and age on the latter three effects. Under the condition of line correlation, SAS 8.1 statistical software was used to make a linear correlation between serum Mg2 + and urinary specific gravity and serum complement C3 level, the correlation between the degree of the strength, the typical representative of the 20 values selected Excel drawing scattered Plot and try to figure out the trend line. Results The urinary specific gravity of patients with high serum Mg2 + level (≥1.1 mmol / L) was lower. The level of complement C3 in patients with low serum Mg2 + level (<0.8 mmol / L) was lower than the normal level. Conclusion Patients with high serum Mg2 + level may be prone to renal insufficiency in early stage. Patients with low serum Mg2 + level may be less immunocompetent and more likely to develop infection.