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为探讨听源性惊厥点燃和前脑结构的关系，用免疫细胞化学方法结合体视学分析，研究了Ｗｉｓｔａｒ种系的听源性惊厥易感大鼠（Ｐ７７ＰＭＣ）惊厥和点燃后，前脑结构内ｃ－ｆｏｓ表达的差异。结果显示，（１）正常Ｗｉｓｔａｒ大鼠接受一次强音刺激后，海马、齿状回、杏仁核、内嗅皮质、嗅周皮质和额－顶皮质内未见Ｆｏｓ阳性神经元；（２）Ｐ７７ＰＭＣ大鼠一次惊厥后，除海马、齿状回外，上述被检各区内可见广泛的Ｆｏｓ阳性神经元，其分布具有区域差异；（３）Ｐ７７ＰＭＣ大鼠点燃后，海马、齿状回内有大量Ｆｏｓ阳性神经元，其他的被检各区内，Ｆｏｓ阳性神经元数量更多，阳性神经元的光密度更大，与一次惊厥后相比较，具有显著差异（Ｐ＜０．０１）。在点燃大鼠海马结构中，齿状回内的Ｆｏｓ免疫反应最强，海马ＣＡ１、ＣＡ２区次之，ＣＡ３区较弱。结果表明，听源性惊厥点燃可以导致海马结构参与到惊厥活动之中。
In order to explore the relationship between auditory convulsion and forebrain structure, we used immunocytochemistry combined with stereological analysis to study the effects of convulsions and ignition on forebrain structure in Wistar susceptible rats (P77PMC) Differences in c-fos expression. The results showed that: (1) Fos positive neurons were not found in hippocampus, dentate gyrus, amygdala, entorhinal cortex, olfactory cortex and frontal cortex in normal Wistar rats after receiving a strong stimulus; (2) P77PMC After a seizure in rats, in addition to the hippocampus and dentate gyrus, a wide range of Fos-positive neurons were found in the above-mentioned seized regions, with a regional difference. (3) After the P77PMC rats were ignited, there were a large number of hippocampus and dentate gyrus Fos-positive neurons. The number of Fos-positive neurons in the other regions was more, and the positive neurons had more optical density, which was significantly different from that after a seizure (P <0.01). In the rat hippocampal formation, the Fos immunoreactivity in the dentate gyrus was strongest, followed by the hippocampal CA1 and CA2 areas and weak in the CA3 area. The results show that auditory convulsion can lead to the involvement of the hippocampus in convulsions.