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目的探讨慢性乙型肝炎病人辅助性T细胞17(Th17)及其相关因子与乙型肝炎病毒(HBV)慢性感染的关系。方法选取78例慢性乙型肝炎病人和23例健康体检者(健康对照组)为研究对象,乙型肝炎病人按病情分为轻、中、重度组。分别检测其血清中的白细胞介素-17(IL-17)、IL-23、IL-1β和IL-6水平以及肝脏损伤指标,并进行统计学分析。结果慢性乙型肝炎各组IL-17、IL-23、IL-1β、IL-6水平均高于健康对照组,差异有统计学意义(F=23.52~219.44,q=10.77~36.18,P<0.05);慢性中度乙型肝炎病人与轻度病人相比,仅IL-6升高;慢性重度乙型肝炎病人与轻、中度病人相比,各因子水平均明显升高,差异有统计学意义(q=6.40~16.80,P<0.05)。慢性乙型肝炎病人血清IL-17含量与血清谷丙转氨酶水平呈正相关(r=0.801,P<0.05),与HBV DNA水平无相关性,与清蛋白和清蛋白/球蛋白比值呈负相关(r=-0.512、-0.547,P<0.05)。结论 Th17细胞参与了慢性乙型肝炎病人肝脏炎症的发生发展过程。
Objective To investigate the relationship between Th17 and its related factors and chronic hepatitis B virus infection in patients with chronic hepatitis B. Methods Totally 78 patients with chronic hepatitis B and 23 healthy subjects (healthy control group) were selected as study subjects. Patients with hepatitis B were divided into mild, moderate and severe groups according to their illness. The levels of IL-17, IL-23, IL-1β and IL-6 in serum were detected and the indexes of liver injury were detected and statistically analyzed. Results The levels of IL-17, IL-23, IL-1β and IL-6 in chronic hepatitis B group were significantly higher than those in healthy controls (F = 23.52-219.44, q = 10.77-36.18, P < 0.05). Only IL-6 increased in patients with chronic moderate hepatitis B compared with those in mild patients. The levels of each factor in chronic severe hepatitis B patients were significantly higher than those in mild and moderate patients Significance (q = 6.40 ~ 16.80, P <0.05). Serum levels of IL-17 in patients with chronic hepatitis B were positively correlated with serum alanine aminotransferase levels (r = 0.801, P <0.05), but not with HBV DNA levels, and negatively correlated with albumin and albumin / r = -0.512, -0.547, P <0.05). Conclusion Th17 cells are involved in the development of liver inflammation in patients with chronic hepatitis B.