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蔡氏等对血液动力学的研究表明,大鼠模拟5,000米高原缺氧10~20天,随着肺动脉压的升高,右心室心肌收缩及舒张性能相应增强,缺氧30~40天则有下降趋势。为探讨这些变化与交感神经系统兴奋性之间可能存在的联系,我们在国内首次以微量(50μl)标本应用COMT放射酶法测定了本原对照及模拟5,000米高原缺氧4天,14天和40天大鼠血浆去甲肾上腺素(NA)与肾上腺素(Ad)的变化。其结果如下:
Chua et al.’s study of hemodynamics showed that hypoxia in 5,000-meter plateau was simulated in rats for 10-20 days. With the increase of pulmonary arterial pressure, systolic and diastolic performance of right ventricle increased correspondingly, while hypoxia decreased 30- 40 days trend. In order to explore the possible relationship between these changes and the excitability of sympathetic nervous system, we first measured microtiter (50μl) COMT radiosurgery in our country for the first time and simulated the hypoxia on the 5,000-meter plateau for 4 days, 14 days and Changes of Plasma Norepinephrine (NA) and Epinephrine (Ad) in 40 Days Rats. The result is as follows: