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早在70年代初,人们就发现杂多酸具有抗病毒活性.例如钨锑酸钠[NaSb_9W_(21)O_(86)]~(18-)有可能成为潜在的抗病毒化合物.非常有趣的是最近报道[NH_4]_(18)[NaSb_9W_(21)O_(86)]·24H_2O(结构代号为HPA-23)具有很高的抗爱滋病病毒活性,在法国已进入临床应用.但从分子水平研究杂多酸化合物抗病毒的机理,目前尚未见到国内外报道.而作为病毒可以广义地看作由一个蛋白外壳包裹,内部则为核酸.爱滋病病毒同样由两层蛋白所包裹,与宿主细胞发生吸附作用主要是通过外层包络蛋白(GP120),该蛋白的活性组分是一个由8个氨基酸组成
As early as the early 1970s, heteropolyacids were found to have antiviral activity, such as sodium tungstate [NaSb_9W_ (21) O_ (86)] ~ (18-), which may become potential antiviral compounds.It is very interesting Recently, it has been reported that [NH_4] _ (18) [NaSb_9W_ (21) O_ (86)] · 24H_2O (HPA-23) has high anti-HIV activity and has been used clinically in France. However, Heteropoly acid compounds antiviral mechanism, has not yet been seen at home and abroad .And as a virus can be broadly regarded as a protein shell, the internal nucleic acid.HIV also wrapped by two layers of protein, and host cells occur Adsorption is mainly through the outer envelope protein (GP120), the active ingredient of the protein is a composed of eight amino acids