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为了探讨脂蛋白原预防Ａｓ作用，将新生乳兔４２只随机分为对照组（Ⅰ）和２个实验组（Ⅱ、Ⅲ）。Ⅱ、Ⅲ组于生后１２ｈ内，分别向腹腔内注射纯化的ＶＬＤＬ０．５ｍｇ／只和１．０ｍｇ／只，第７、１５天等剂量强化１次。１７周后开始高胆固醇饲料Ａｓ造型，至第４０周处死取升、胸、腹主动脉，作动脉内侧壁观察及组织病理学检查分析。结果表明，Ⅰ组ＡＡ％明显大于Ⅱ、Ⅲ组（Ｐ＜０．０１），Ⅱ、Ⅲ组也有差异。以病变的程度划分为０、１、２、３等级，经Ｒｉｄｉｔ分析表明Ⅰ组病变程度显著高于Ⅱ、Ⅲ组，Ⅰ组全部呈现典型的ＡＳ病理改变。本研究证实生命早期脂蛋白原接种有抗Ａｓ作用。
In order to investigate the effect of lipoprotein against As, 42 neonatal rabbits were randomly divided into control group (Ⅰ) and two experimental groups (Ⅱ, Ⅲ). Groups Ⅱ and Ⅲ were injected intraperitoneally with purified VLDL 0.5 mg / kg and 1.0 mg / kg intraperitoneally within 12 hours after birth, respectively. After 17 weeks, the high-cholesterol diet As model was started. At the 40th week, the rats were sacrificed and their thoracic and abdominal aortas were taken for observation and histopathological examination. The results showed that the AA% in group Ⅰ was significantly higher than that in groups Ⅱ and Ⅲ (P <0.01), and there were also differences in group Ⅱ and Ⅲ. The degree of lesion was divided into 0, 1, 2, and 3 levels. Ridit analysis showed that the degree of lesion in group Ⅰ was significantly higher than that in group Ⅱ and Ⅲ. All of group Ⅰ showed typical pathological changes of AS. This study demonstrates that early life pro-lipoprotein inoculation has an anti-As effect.