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40年来,食道静脉曲张出血病人的病死率几乎无变化.目前正在探索应用药物疗法,例如心得安、生长激素释放抑制因子(Somatostatin)、甲氰咪胍、甲硝呋胍(ranitidine)等,其中以心得安最引人注目.心得安是作用短暂的β受体阻断药,对心脏无选择性作用,为脂溶性化合物.口服后,其代谢主要取决于肝脏药物代谢酶系统的活性,特别是细胞色素P-450的活性,所产生有活性的代谢产物则由肾脏排
There has been almost no change in the case fatality rate in patients with esophageal variceal bleeding over the past 40 years, and therapeutic drug use such as propranolol, somatostatin, cimetidine, ranitidine and the like have been explored In order to feel the most compelling, propranolol is a short-acting beta-blocker, has no selective effect on the heart and is a fat-soluble compound, which, after oral administration, depends primarily on the activity of the liver drug metabolizing enzyme system, Is cytochrome P-450 activity, the resulting metabolites produced by the kidney row