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本文对支气管哮喘、喘息型支气管炎患者共43例日服茶碱缓释片后,用紫外分光光度计测定血药浓度的变化及某些药代动力学参数。其中4例经测定半衰期为16.86±2.16小时,表现分布容积为28.37±2.58 L,血药峰值为5.74±0.27μg/ml,达峰时间为4.74±0.41小时,血药浓度曲线表现峰型平坦,有效浓度维持时间长。临床症状与肺功能得到改善,尤其是对控制夜间发作效果较好。对应用茶碱类药物患者,进行血药浓度及药代动力学测定临床上是重要的。
In this paper, a total of 43 patients with bronchial asthma, asthmatic bronchitis were treated with theophylline sustained-release tablets, UV spectrophotometer determination of plasma concentration changes and some pharmacokinetic parameters. Among them, 4 cases had a measured half-life of 16.86 ± 2.16 hours, a volume of 28.37 ± 2.58 L, a peak blood level of 5.74 ± 0.27 μg / ml, and a peak time of 4.74 ± 0.41 hours. The plasma concentration curve showed a flat peak shape, Effective concentration to maintain a long time. Clinical symptoms and lung function are improved, especially for the control of nocturnal attacks better. For the theophylline drugs in patients with plasma concentration and pharmacokinetic determination of clinically important.