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目的:观察静脉注射盐酸关附甲素对阵发性室上性心动过速的疗效与安全性。方法:入选在我院急诊科或心内科病房住院的阵发性室上性心动过速患者40例,按4:1的比例,随机分为关附甲素组与普罗帕酮组,按个体化原则给予静脉推注。结果:关附甲素组总有效率为78.1％,平均起效时间为(4.9±3.3)min;普罗帕酮组总有效率87.5％,平均起效时间(8.1±4.6)min。2组患者用药后的血压无明显变化。关附甲素组中3例患者在室上速终止时出现偶发室早,1例患者出现舌麻;普罗帕酮组1例患者出现偶发室早。结论:盐酸关附甲素能有效终止阵发性室上性心动过速,不良反应少。
OBJECTIVE: To observe the efficacy and safety of intravenous injection of Guan Fugan Hydrochloride on paroxysmal supraventricular tachycardia. Methods: Forty patients with paroxysmal supraventricular tachycardia who were hospitalized in our emergency department or cardiology ward were randomly divided into three groups according to the ratio of 4: 1. The principle of intravenous injection. Results: The total effective rate was 78.1% and the mean effective time was (4.9 ± 3.3) min. The total effective rate was 87.5% in propafenone group and the mean effective time was 8.1 ± 4.6 min. There was no significant change in blood pressure after treatment in two groups. Three patients in the A group received sporadic premature ventricular tachycardia at the termination of SVS, and one patient developed lingual hemp. One patient in propafenone group had occasional premature ventricular contractions. Conclusion: Guan Fu hydrochloride hydrochloride can effectively stop paroxysmal supraventricular tachycardia with few adverse reactions.