论文部分内容阅读
许多资料证明利血平抗心律失常具有良好的作用,但在小儿方面的资料尚未见报告。利血平作用机理与生物活性物质(儿茶酚胺、5-羟色胺)代谢有关。利血平能消耗心脏、脑、交感神经等组织内的儿茶酚胺和5-羟色胺含量,并有抗组织胺功能。作者也观察到利血平治疗小儿心律失常出现临床效果时,患儿血5-羟色胺含量确实降低。作者为研究利血平的疗效,观察治疗60例(男女各30例)4～14岁心律失常患儿,其中异位性心动过速22例(阵发性6例,复发性12例,顽固性4例),期外收缩36例(室上性19例,室性17例),窦性心动过速2例。30例期外收缩是频发(15～40次/分)。全部患儿心律失常病因均为心外因素。38例心律失常长期存在(1～6年),对30例进行了长达6年之观察。54例为治疗,6例为预防应用利血平,利血平的剂量决定于小儿年龄、心律失常类型和治疗效果。常规剂量为0.01mg/kg/日。开始时宜小量0.05～0.1～0.2mg/日,无效时再增加到0.3～0.5mg/日,分3～4次口服,达到效果后剂量可逐渐减低,以有效量维持,疗程不应少于两周,可长达45天或更久。观察
Many data prove that reserpine anti-arrhythmia has a good effect, but in the children’s information has not been reported. Reserpine mechanism of action and bioactive substances (catecholamines, serotonin) metabolism. Reserpine can consume the catecholamines and serotonin content of the heart, brain, sympathetic and other tissues, and anti-histamine function. The authors also observed that reserpine treatment of pediatric arrhythmias clinical effect, children with serum serotonin did reduce. In order to study the effect of reserpine, 60 patients (30 males and 30 females) with arrhythmia of 4-14 years old were observed and treated. Twenty-two of them were ectopic tachycardia (paroxysmal 6 cases, recurrent 12 cases, stubborn 4 cases of sexual), 36 cases of extrasystoles (19 cases of supraventricular, 17 cases of ventricular), sinus tachycardia in 2 cases. 30 cases of extra-term contraction is frequent (15 to 40 beats / min). All causes of cardiac arrhythmia in children are extra-cardiac factors. 38 cases of arrhythmia long-term existence (1 to 6 years), 30 cases were observed for up to 6 years. 54 were treated, and 6 were prophylactic reserpine. The dose of reserpine depends on pediatric age, type of arrhythmia, and the effect of treatment. The usual dose is 0.01 mg / kg / day. The beginning of a small amount of 0.05 ~ 0.1 ~ 0.2mg / day, and then increased to 0.3 ~ 0.5mg / day, 3 to 4 times orally, to achieve the effect of dose can be gradually reduced to maintain an effective amount, the treatment should not be less than Two weeks, up to 45 days or longer. Observed