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目的针对尼可地尔对老年急性非ST段抬高心肌梗死患者冠状动脉(冠脉)血流量及心功能的影响进行分析研究。方法 120例急性非ST段抬高心肌梗死患者,随机分为对照组和观察组,各60例。对照组实施常规治疗,观察组在对照组的基础上加用尼可地尔治疗。对两组患者进行心电图、心脏彩超、肌钙蛋白等诊断检查,对两组患者的心功能、冠脉血流量等进行比较。结果观察组患者治疗后的左室射血分数、脑钠肽与治疗前比较,差异有统计学意义(P<0.05);观察组患者的心肌肌钙蛋白I治疗后的下降程度与对照组比较差异有统计学意义(P<0.05);观察组患者治疗7、14 d的心电图检查ST段恢复至基准线患者所占的比例为53.33%、85.00%高于对照组的40.00%、66.67%,差异有统计学意义(P<0.05)。结论在急性非ST段抬高心肌梗死患者治疗中,尼可地尔可以改善患者的心功能,有效改善患者的冠状动脉血流量,同时还可以对老年急性非ST段抬高心肌梗死患者的心肌有良好的保护作用,可以在临床治疗中进行推广应用。
Objective To analyze the influence of nicorandil on coronary artery (coronary) blood flow and cardiac function in elderly patients with acute non-ST segment elevation myocardial infarction. Methods A total of 120 patients with acute non-ST segment elevation myocardial infarction were randomly divided into control group and observation group, with 60 cases in each group. The control group was given routine treatment. The observation group was treated with nicorandil on the basis of the control group. The two groups of patients were diagnosed by electrocardiogram, echocardiography and troponin, and their cardiac function and coronary blood flow were compared between the two groups. Results After treatment, the left ventricular ejection fraction and brain natriuretic peptide in the observation group were significantly different from those before treatment (P <0.05). Compared with the control group, the decrease of cardiac troponin I in the observation group The difference was statistically significant (P <0.05). The percentage of ST segment recovering to baseline in electrocardiogram examination was 53.33% in the observation group, 85.00% in the observation group was 40.00% and 66.67% in the control group, The difference was statistically significant (P <0.05). Conclusion Nicorandil can improve cardiac function in patients with acute non-ST-elevation myocardial infarction and improve coronary blood flow in patients with acute non-ST-segment elevation myocardial infarction Have a good protective effect, can be applied in clinical treatment.