论文部分内容阅读
本文报道用放射免疫分析法测定家免ⅳ国产促甲状腺激素释放激素(TRH)后的药时变化及其在各组织器官的分布。结果表明,家兔ⅳ不同剂量TRH后,其血药浓度变化均表现为二室开放模型。家兔ⅳ TRH 0.8mg/kg时,时,时,家兔ⅳ TRH 2min后,即广泛分布于各组织器官,以垂体和肾脏浓度为最高,其他依次为体脂,腹直肌、小肠、心脏、生殖腺,脾、下丘脑、肝脏。TRH大部在血中降解,其他主要经肾排泄,给药后5min排出给药量的1.0％,2h后排出21.9％。
This article reports the use of radioimmunoassay method for determination of home-made thyrotropin-releasing hormone (TRH) after the drug changes and distribution in various tissues and organs. The results showed that the rabbit plasma levels of TRH after different doses of TRH showed a two-compartment open model. Rabbits ⅳ TRH 0.8mg / kg, when, rabbits ⅳ TRH 2min, that is widely distributed in various tissues and organs, the highest concentration of pituitary and kidney, the other followed by body fat, rectus abdominis, small intestine, heart , Gonads, spleen, hypothalamus, liver. Most of the TRH was degraded in the blood, the other mainly excreted by the kidneys, 1.0% of the administered dose was discharged 5 minutes after administration and 21.9% after 2 hours.