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Hepatitis E virus(HEV)is an unclassified,small,non-enveloped RNA virus,as a causative agent of acute hepatitisE that is transmitted principally via the fecal-oral route.Thevirus can cause large water-born epidemics of the diseaseand sporadic cases as well.Hepatitis E occurs predominantlyin developing countries,usually affecting young adults,witha high fatality rate up to 15-20% in pregnant women.However,no effective treatment currently exists for hepatitisE,and the only cure is prevention.But so far there are nocommercial vaccines for hepatitis E available in the world.Although at least four major genotypes of HEV have beenidentified to date,only one serotype of HEV is recognized.So there is a possibility to produce a broadly protectivevaccine.Several studies for the development of an effectivevaccine against hepatitis E are in progress and the bestcandidate at present for a hepatitis E vaccine is a recombinantHEV capsid antigen expressed in insect cells from abaculovirus vector.In this article,the recent advances ofhepatitis E and the development of vaccine research forHEV including recombinant protein vaccine,DNA vaccineand the recombinant hepatitis E virus like particles(rHEVVLPs)are briefly reviewed.
The virus can cause large water-born epidemics of the disease and sporadic cases as well.Hepatitis E occurs predominantlyin developing countries, usually affecting young adults, witha high fatality rate up to 15-20% in pregnant women. However, no effective treatment currently exists for hepatitis E, and the only cure is prevention.But so far there are are nocommercial vaccines for hepatitis E available in the world. Yet at least four major genotypes of HEV have been identified to date, only one serotype of HEV is recognized. there there is a may to produce a broad protective vacccine. Research studies for the development of an effective vaccination against hepatitis E are in progress and the best candidate at present for a hepatitis E vaccine is a recombinant HEV capsid antigen expressed in insect cells from abaculovirus vector. In thi s article, the recent advances of hepatitis E and the development of vaccine research for HEV including recombinant protein vaccine, DNA vaccine and the recombinant hepatitis E virus like particles (rHEVVLPs) are briefly reviewed.