论文部分内容阅读
目的 观察慢性乙型肝炎的肝脏微循环变化并探讨其发生机制。方法 对 141例慢性乙型肝炎病人进行肝活检 ,活检组织行光镜观察 ,其中 5 3例还进行了电镜观察。结果 慢性乙型肝炎患者 ,包括肝功能正常者存在肝脏微循环障碍 ,在光镜下主要表现为肝窦腔内红细胞聚集 ,电镜下主要表现为肝窦毛细血管化。电镜观察的 5 3例中有 2 6例肝窦内皮细胞中发现Weibel Palade小体。淋巴细胞、枯否氏细胞及肝窦内皮细胞间发生密切联系。结论 慢性乙型肝炎患者存在肝脏微循环障碍。肝窦内皮细胞中出现Weibel Palade小体可能是肝脏微循环障碍发生的关键环节。
Objective To observe the changes of liver microcirculation in chronic hepatitis B and to explore its mechanism. Methods One hundred and seventy-one patients with chronic hepatitis B underwent liver biopsy. The biopsy specimens were examined by light microscopy. Fifty-three patients were also examined by electron microscopy. Results There were liver microcirculation disorders in patients with chronic hepatitis B, including liver dysfunction. In light microscope, the main manifestations of the disease were the aggregation of red blood cells in the hepatic sinusoid cavity, the main manifestation of which was liver cirrhosis by electron microscopy. Weibel Palade bodies were found in 26 cases of sinusoidal endothelial cells in electron microscopy. Lymphocytes, Kupffer cells and sinusoidal endothelial cells are closely related. Conclusion Chronic hepatitis B patients have liver microcirculation disorder. The presence of Weibel Palade bodies in sinusoidal endothelial cells may be a key link in the development of microcirculation disturbance in the liver.