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大环内酯类抗生素是碱性化合物,难溶于水,在碱性的肠环境中易被吸收,对酸不稳定,但新的半合成衍生物,如罗希红霉素(roxithromycin)和阿齐红霉素(azithromycin)在酸性条件下具有增加稳定性的特征。大环内酯类抗生素有高的脂溶性,所以对
Macrolide antibiotics are basic compounds that are poorly soluble in water and readily absorbed in alkaline enteric environments and are not stable to the acid but new semisynthetic derivatives such as roxithromycin and azithromycin Azithromycin has the property of increasing stability under acidic conditions. Macrolide antibiotics have high fat solubility, so right