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①目的检测血管内皮生长因子-C(VEGF-C)及其受体(Flt-4)在大肠癌中的表达,探讨二者在大肠癌淋巴管生成及淋巴结转移中的作用。②方法以80例大肠癌标本作为研究对象,15例大肠粘膜作为对照,采用流式细胞术分析,分别检测VEGF-C和Flt-4的表达在不同指标及临床病理特征之间的关系。③结果大肠癌组织中VEGF-C及Flt-4的表达量高于正常粘膜,VEGF-C及Flt-4在大肠癌中的表达都与分化程度、Dukes分期及淋巴结转移有关,且二者呈正相关。④结论VEGF-C可能在大肠癌癌变过程中起一定促进作用,VEGF-C及其受体介导的调控系统与大肠癌组织的淋巴管生成及肿瘤细胞的淋巴结转移密切相关。
Objective To detect the expression of vascular endothelial growth factor-C (VEGF-C) and its receptor (Flt-4) in colorectal cancer and explore its role in lymphangiogenesis and lymph node metastasis in colorectal cancer. Methods 80 cases of colorectal cancer as research object, 15 cases of colorectal mucosa as a control, using flow cytometry analysis of VEGF-C and Flt-4 expression in different indicators and the relationship between clinicopathological features. Results The expression of VEGF-C and Flt-4 in colorectal carcinoma was higher than that in normal mucosa. The expressions of VEGF-C and Flt-4 in colorectal carcinoma were all related to the differentiation degree, Dukes staging and lymph node metastasis, and both were positive Related. ④Conclusion VEGF-C may play a role in carcinogenesis of colorectal cancer. VEGF-C and its receptor-mediated regulatory system are closely related to lymphangiogenesis and lymph node metastasis of colorectal cancer.