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目的 :探讨特发性全面强直阵挛发作 (generalizedtonicclonicseizure ,GTCS)癫患者发作间期局部脑血流 (rCBF)特征。方法 :用单光子发射计算机断层显像 ( 99Tcm ECD SPECT)技术对 2 0例新发病的特发性GTCS患者发作间期rCBF特征进行观察 ,以兴趣区(ROI)法作半定量分析。结果 :2 0例新发病的特发性GTCS患者发作间期rCBF异常率为 3 0 % ( 6例 ) ,主要表现为一侧丘脑区或基底节区的放射性稀疏。结论 :新发病的特发性GTCS患者的rCBF存在两种特征 :①正常的CBF ;②一侧丘脑区CBF降低 ,CBF降低的丘脑区可能为亚临床病灶
Objective: To investigate the characteristics of regional cerebral blood flow (rCBF) in patients with idiopathic generalized tonic clonic seizure (GTCS) epilepsy. Methods: The characteristics of rCBF during interictal seizures of 20 newly diagnosed idiopathic GTCS patients were observed by single photon emission computed tomography (99Tcm ECD SPECT) technique. The ROI method was used for semiquantitative analysis. Results: The abnormal rate of rCBF in 20 newly diagnosed idiopathic GTCS patients was 30% (6 cases), which mainly manifested as sparse radioactivity in one thalamus or basal ganglia. CONCLUSIONS: There are two characteristics of rCBF in newly diagnosed idiopathic GTCS patients: ① normal CBF; ② CBF decreased in one thalamus, while thalassemia decreased in CBF may be subclinical lesion