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目的建立一种简单、有效地制备N-苄基苯甲酰胺类化合物的方法。方法以苄胺及衍生物为底物、TBHP为氧化剂、HPO(OEt)_2为添加剂,在CuBr_2/Ag_2CO_3的催化下,制备N-苄基苯甲酰胺类化合物。结果和讨论制备了一系列N-苄基苯甲酰胺类化合物,其结构经~1HNMR、~(13)CNMR和HR-MS表征。该反应具有操作简便、原料易得、条件温和等特点。
Objective To establish a simple and effective method for the preparation of N-benzyl benzamide compounds. Methods Benzylamine and its derivatives as substrates, TBHP as oxidant and HPO (OEt) _2 as additives, N-benzylbenzamides were prepared under the catalysis of CuBr_2 / Ag_2CO_3. Results and Discussion A series of N-benzyl benzamides were prepared and their structures were characterized by ~ 1HNMR, ~ (13) CNMR and HR-MS. The reaction has the advantages of easy operation, easy access to raw materials, mild conditions and the like.