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目的 :探讨血清中白细胞介素 - 6(IL- 6)水平与宫内节育器 (IUD)存在的关系。方法 :采用酶联免疫吸附试验测定 64例置器妇女 (试验组 ,试验组又分为置器出血组和无出血组 ) ,以及60例健康妇女 (对照组 )血清中 IL- 6水平 ,同时测定两组血清中 C-反应蛋白 (CRP)水平。结果 :试验组 64例中有 31例血中 IL- 6水平升高 ,与对照组相比差异显著 (P<0 .0 1 )。但其中置器出血组与不出血组中 IL- 6水平无统计学差异 (P>0 .0 5)。试验组及对照组血清中 CRP检验结果均为阴性。结论 :宫内节育器引起子宫内膜无菌性炎症反应 ,导致部分妇女血清中 IL- 6水平升高。IL- 6可能在宫内节育器的避孕机理中起重要作用
Objective: To investigate the relationship between interleukin - 6 (IL - 6) level in serum and the presence of intrauterine device (IUD). Methods: The levels of IL-6 in sera of 64 female patients (experimental group, experimental group and bleeding group) and 60 healthy women (control group) were measured by enzyme-linked immunosorbent assay Serum levels of C-reactive protein (CRP) were measured in both groups. Results: IL-6 levels in 31 of the 64 patients in the experimental group were significantly higher than those in the control group (P <0.01). However, there was no significant difference in the level of IL-6 between the hemorrhage and untreated group (P> 0.05). Serum CRP test results of the test group and the control group were negative. Conclusion: The IUD causes aseptic inflammatory reaction in the endometrium, resulting in elevated serum IL-6 levels in some women. IL-6 may play an important role in the contraceptive mechanism of IUD