澳研究组克隆出人类FSH抑制素

• 作 者: 许侠
• 出 处: 国外医学情报
• 发表日期: 1987年04期
• 关键词: 抑制素 FSH 生殖机能 生殖激素 避孕药 输精管 基因工程方法 卵泡刺激素 类激素 解剖学

洛杉矶消息:一种难以捉摸的人类激素的克隆使男女避孕出现了全新的途径,并为生殖机能障碍提供了一个新的诊断方法。在对主要的一种生殖激素(称为抑制素)理论了解50年之后,澳大利亚研究人员已使少量抑制素纯化,并用基因工程方法大量生产。已知抑制素在睾丸输精管的Sertole氏细胞产生,抑制卵泡刺激素(FSH)的释放。澳大利亚墨尔本Monash大学解剖学教授David de Kretser说:“人体内只产生微量的抑制素,因而不可能分离出足够的量进行研究,更不用说用它作避孕药。”

LOS ANGELES (Reuters) - Cloning of an elusive human hormone has brought a whole new way of contraception for men and women and provided a new diagnostic method for reproductive dysfunction. Fifty years after understanding the theory of one of the major reproductive hormones known as statins, Australian researchers have made small amounts of inhibin purified and genetically engineered for mass production. Inhibitors are known to produce Sertole cells in the testis vas deferens and inhibit the release of follicle stimulating hormone (FSH). David de Kretser, professor of anatomy at Monash University in Melbourne, Australia, said: “The body produces only small quantities of inhibin, making it impossible to isolate enough to study, let alone use it as a pill.”