丘脑皮层通路神经元的伤害性反应(英文)

• 作 者: 罗非 王锦琰
• 机 构: 中国科学院心理研究所,中国科学院心理健康重点实验室,
• 出 处: Neuroscience Bulletin
• 发表日期: 2009年05期
• 关键词: 感觉编码 痛觉 丘脑皮层通路 丘脑 慢性疼痛 伤害性 脑功能成像 脑机制 神经网络 sensory

痛觉对于人类和动物的生存具有重要意义,但其脑机制长期不明。大脑如何解码痛觉诱发活动,并最终形成对于疼痛的知觉经验?在过去10年间,人们综合运用电生理、脑功能成像以及行为学手段开展了大量研究,试图回答这一问题。这些研究已经开始揭示疼痛形成的一些基本特征。人们逐渐认识到,参与痛觉信息传递和处理的是一个庞大的分布式神经网络。这些研究对于促进慢性疼痛新疗法的出现具有重要意义。

Pain sensation is of great importance for the survival of humans and animals, but its long-standing brain mechanism is unknown. How does the brain decode pain-inducing activity and eventually develop a perception of pain? In the past decade, extensive research has been conducted using electrophysiology, brain imaging, and behavioral approaches in an attempt to answer this question. These studies have begun to reveal some of the basic characteristics of pain formation. It is gradually realized that the participation in pain information transmission and processing is a huge distributed neural network. These studies are of great importance to promote the emergence of new treatments for chronic pain.