ROLE OF CALCIUM IN ELECTRO-ACUPUNCTURE ANALGESIA AND THE DEVELOPMENTS OF ANALGESIC TOLERANCE TO ELEC

• 作 者: 张祖暄 张媛贞 贾淑萍 陆学健 余瑞荣 王新光 陈荣三
• 机 构: Division of Physiology, Department of Biology, Nanjing University,Division of Physiology, Department
• 出 处: Science in China,Ser.B
• 发表日期: 1987年09期
• 关键词: morphine acupuncture analgesic analgesia naloxone inhibited mutual finding antag

Role of brain Ca~(2+) in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibiturs of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca~(2+) and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca~(2+) and cAMP levels in the animals greatly reduced. From the changes of brain Ca~(2+) and cAMP levels, the analgesic effects by electro-acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morphine. These finding

Role of brain Ca ~ (2+) in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibiturs of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca ~ (2+) and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of the analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca ~ (2+) and cAMP levels in the animals greatly reduced. From the changes of brain Ca ~ (2+) and cAMP levels, the analgesic effects by electro -acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morph ine. These finding