论文部分内容阅读
目的研究系统干预对鼻咽癌同期调强适形放疗和静脉化疗(以下简称同期放化疗)口腔黏膜炎的影响。方法 105例鼻咽癌同期放化疗的患者随机分为观察组57例,对照组48例,对照组按鼻咽癌患者放疗临床干预路径进行干预;观察组在对照组的基础上给予系统干预。结果观察组口腔黏膜反应的发生时间、分级明显低于对照组。观察组均按计划治疗结束,对照组有10例因口腔黏膜疼痛难忍中断放疗3~5d后继续放疗至治疗结束。差异有统计学意义(P<0.05)。结论系统干预可延缓鼻咽癌患者口腔黏膜反应发生的时间、降低反应分级和并发症的发生率。
Objective To study the effects of systemic intervention on oral mucositis in concurrent nasopharyngeal carcinoma with conformal radiotherapy and intravenous chemotherapy (hereinafter referred to as concurrent chemoradiotherapy). Methods A total of 105 patients with concurrent nasopharyngeal carcinoma treated by radiotherapy and chemotherapy were randomly divided into observation group (n = 57) and control group (n = 48). The control group was intervened by the pathological intervention of radiotherapy for patients with nasopharyngeal carcinoma. The observation group received systematic intervention on the basis of the control group. Results The incidence of oral mucosal reaction in the observation group was significantly lower than that in the control group. The observation group were treated as planned. In the control group, 10 patients died of oral mucosal pain for 3 to 5 days and then continued radiotherapy until the end of treatment. The difference was statistically significant (P <0.05). Conclusions Systemic intervention can delay the occurrence of oral mucosal reaction in patients with nasopharyngeal carcinoma and reduce the incidence of response grading and complications.