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目的探讨单唾液酸四己糖神经节苷脂(GM1)与缺血缺氧性脑病(HIE)新生儿血清中脑源性神经营养因子(BDNF)和神经元特异烯醇化酶(NSE)的关系。方法选取2014年2月-2016年2月期间济宁市第一人民医院收治的224例HIE新生儿为研究对象,随机分为观察组与对照组,每组112例。对照组患儿给予常规治疗,观察组患儿在对照组的基础上应用GM1进行治疗。检测所有患儿自出生后第1、3、7、10、14天的血清BDNF和NSE的水平。结果两组患儿经治疗后血清BDNF均逐渐升高,在出生后第10天开始下降,且观察组患儿出生后血清BDNF水平升高较对照组更为明显(均P<0.001);两组患儿中病情分度越重,血清NSE水平越高,且观察组患儿出生后血清NSE水平下降较对照组更为明显(均P<0.05),而出生后第10天开始两组患儿的血清NSE水平的比较,差异无统计学意义(均P>0.05)。结论 GM1能有效改善HIE患儿的血清BDNF和NSE,减轻脑损伤,促进脑发育和改善预后,明显提高治疗效果。
Objective To investigate the relationship between monosialotetrahexosyl gangliosides (GM1) and serum brain-derived neurotrophic factor (BDNF) and neuron specific enolase (NSE) in neonates with hypoxic-ischemic encephalopathy (HIE) . Methods A total of 224 HIE newborns admitted to Jining First People’s Hospital from February 2014 to February 2016 were selected as study subjects and randomly divided into observation group and control group with 112 cases in each group. The control group of children given conventional treatment, the observation group of children in the control group based on the application of GM1 treatment. All children were tested for serum BDNF and NSE levels on days 1, 3, 7, 10, and 14 after birth. Results After treatment, the serum BDNF in both groups gradually increased and began to decline on the 10th day after birth. The serum BDNF level in the observation group was significantly higher than that in the control group after birth (both P <0.001) The more severe the disease was, the higher the level of serum NSE was and the lower the serum NSE level in the observation group was (P <0.05). But the incidence of NSE in the observation group was significantly lower than that in the control group Children’s serum NSE levels, the difference was not statistically significant (P> 0.05). Conclusion GM1 can effectively improve the serum levels of BDNF and NSE in children with HIE, relieve brain injury, promote brain development and improve prognosis, and obviously improve the therapeutic effect.