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众所周知,肼苯哒嗪可诱发系统性红斑狼疮(SLE)样综合征,据认为这种并发症不影响肾脏,消退后不遗留永久后遗症。肼苯哒嗪引起的肾脏病过去罕有报道,而且与肼苯哒嗪的关系难以估计。作者报道8例与肼苯哒嗪有关的急进型肾小球肾炎,停药后好转。本组患者平均年龄58岁,均因肾功能损害而入院,除2例伴有糖尿病外其余无伴发病,6例有原发性高血压,但在肼苯哒嗪治疗前无肾脏异常体征。全部患者均有镜下血尿及蛋白尿,抗核抗体试验阳性,
It is well-known that hydralazine can induce systemic lupus erythematosus (SLE) -like syndrome. It is believed that this complication does not affect the kidneys, leaving no permanent sequelae after resolution. Kidney disease caused by hydralazine has been rarely reported in the past, and the relationship with hydralazine is difficult to estimate. The authors report 8 cases of acute renal glomerulonephritis associated with hydralazine, after stopping the improvement. The average age of this group of patients was 58 years old, were admitted to hospital due to renal dysfunction, in addition to 2 cases with diabetes mellitus without disease, 6 cases of essential hypertension, but before hydralazine treatment no signs of kidney abnormalities. All patients had microscopic hematuria and proteinuria, anti-nuclear antibody test was positive,