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基于液相色谱-电感耦合等离子体质谱联用方法,研究了低浓度奈达铂在纯水、9 g/L NaCl溶液和人血浆中的稳定性和分解产物。结果表明,72 h内奈达铂在纯水和血浆中稳定,在9 g/L NaCl溶液中易分解为顺铂。基于凝胶色谱-电感耦合等离子质谱联用方法,研究了低浓度顺式-二碘-(1R,2R)-(-)-1,2-环己二胺合铂(II)(DPI)在纯水、9 g/L NaCl溶液和人血浆中的稳定性和分解产物。结果表明,DPI在3种体系中均不稳定,方法检出限为0.4ng/mL(以铂计)。研究了DPI在9 g/L NaCl溶液中的水解过程,通过同时分析铂元素和碘元素形态确定了水解机理。
The stability and degradation products of low concentration nedaplatin in pure water, 9 g / L NaCl solution and human plasma were studied based on liquid chromatography-inductively coupled plasma mass spectrometry. The results showed that within 72 h, Nedaplatin was stable in pure water and plasma and easily decomposed to cisplatin in 9 g / L NaCl solution. The effect of low concentration of cis - diiodo - (1R, 2R) - (-) - 1,2-cyclohexanediamine platinum (II) Pure water, 9 g / L NaCl solution and stability and decomposition products in human plasma. The results showed that DPI was not stable in all three systems. The detection limit was 0.4ng / mL (based on platinum). The hydrolysis of DPI in 9 g / L NaCl solution was studied. The hydrolysis mechanism was confirmed by simultaneous analysis of the platinum and iodine forms.