肿瘤蛋白的免疫学分析

• 作 者: Moore J P 孟祥金
• 出 处: 国外医学(肿瘤学分册)
• 发表日期: 1988年02期
• 关键词: 免疫学分析 静止细胞 肿瘤蛋白 生物化学信号 肿瘤基因 生长因子受体 细胞核 突变蛋白 细胞生长 免疫沉淀

原肿瘤基因(proto-oncogens)中的ras家族(N-ras,Ki-ras和Ha-ras)和myc家族(c-myc,N-myc和L-myc)是调节细胞生长结构的组成部分。ras蛋白与GTP相连,并且与启动生长因子受体使静止细胞生长的生物化学信号的转导有关。通过增加c-myc的表达,细胞很快便对这些信号反应。每个myc蛋白都位于细胞核中,尽管推断c-myc可能有几种作用,但它们的功能尚不能确定。对几种人类肿瘤发生的研究提示,ras和myc基因存在异常表达,表现为突变蛋白的产生或正常蛋白

The ras family (N-ras, Ki-ras and Ha-ras) and the myc family (c-myc, N-myc and L-myc) in proto-oncogens are part of a regulatory cell growth architecture. The ras protein is linked to GTP and is involved in the transduction of biochemical signals that initiate growth cell growth by quiescent cells. By increasing c-myc expression, cells quickly respond to these signals. Each myc protein is located in the nucleus. Although it is inferred that c-myc may have several effects, its function is uncertain. Studies of several human tumors suggest that ras and myc genes are abnormally expressed as mutein production or normal protein