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本实验研究了国产羧甲基淀粉(CMS)对小鼠产生 IgE及 IgM抗体和对小鼠胸腺及脾脏重量的影响,结果证明,无论给予或不给予小剂量环磷酰胺(Cy),CMS均能显著或非常显著地抑制小鼠体内诱生抗绵羊红细胞(SRBC)的 IgM直接空斑形成细胞(PFC)数及显著降低小鼠产生抗 SRBC的凝集抗体效价;卵清蛋白致敏的小鼠如加注 Cy能促进IgE产生,但若使用CMS,即使给 Cy仍能非常显著地抑制抗卵清蛋白的 IgE产生。单用CMS能显著增高胸腺的重量,但对脾脏重量无明显影响。机理可能与该药能促进胸腺发育而产生或激活较多的T抑制细胞有关,提示 CMS可能具有免疫调节效应。
In this study, we investigated the effects of domestic CMS on the IgE and IgM production in mice and on the weight of thymus and spleen in mice. The results showed that both CMS and Cystatin (CMS), with or without small dose of cyclophosphamide (Cy) Can significantly or very significantly inhibit the number of IgM direct plaque forming cells (PFCs) induced by anti-sheep erythrocytes (SRBC) in mice and significantly reduce the titer of agglutinating antibodies produced by mice against SRBC; the ovalbumin-sensitized small IgE production was promoted by the addition of Cy as a mouse, but inhibition of IgE production by anti-ovalbumin was very significant even if Cy was used. Single use of CMS can significantly increase the weight of the thymus, but no significant effect on the weight of the spleen. Mechanism may be related to the drug can promote the development of thymus to produce or activate more T suppressor cells, suggesting that CMS may have immunomodulatory effects.