12-钨硼酸5-氟尿嘧啶盐的合成及抗癌活性研究

• 作 者: 李娟 李静 齐燕飞 王宏芳 王恩波 胡长文 许林 吴新宇
• 机 构: 东北师范大学化学学院多酸化学研究所,吉林大学公共卫生学院,东北师范大学化学学院多酸化学研究所,吉林大学公共卫生学院,东北师范大学化学学院多酸化学研究所,东北师范大学化学学院多酸化学研究所,东北师范大学
• 出 处: 高等学校化学学报
• 发表日期: 2004年06期
• 关键词: 钨硼酸 5-氟尿嘧啶 合成 抗癌活性

5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD_ 50 of WBF orally administrated to mice is 1 117.4 mg/kg. [WT5HZ]

5-Fluorouracil salt (WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1 H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer The acute toxicity of WBF was carried out. The half toxicity dose LD_50 of WBF orally administrated to mice is 1 117.4 mg / kg. [WT5HZ]