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目的分析某基层医院不良反应(ADR)发生特点。方法对该院2014年1月至12月医院医务人员呈报158份ADR报告进行回顾性分析。结果 158份ADR报告中,ADR男女发生比例为1.2∶1;70岁以上老年人ADR比例最高(45例,28.48%);静脉注射较其他给药途径更易发生ADR(113例,71.52%);其中抗感染药物引起的ADR比例最多(81例,51.27%),其次是中药制剂(30例,18.99%);ADR主要临床表现皮疹、瘙痒等皮肤及其附件损伤为主(68例,43.04%),其次为消化系统损伤(34,21.52%)。结论 ADR的监测和上报工作,有利于掌握更多的药品信息,规范临床合理用药,控制不良反应发生的风险,保证患者用药安全。
Objective To analyze the characteristics of adverse reactions (ADR) in a primary hospital. Methods A retrospective analysis of 158 ADR reports submitted by hospital medical staff from January to December in 2014 was conducted. Results The incidence of ADR was 1.2:1 in 158 ADR patients. The ADR was the highest in 45 elderly patients over the age of 70 (28.48%). ADR was more likely to occur in 113 RA patients (71.52%) than other routes of administration. Among them, ADR caused by anti-infective drugs was the most (81 cases, 51.27%), followed by traditional Chinese medicine preparations (30 cases, 18.99%). The main clinical manifestations of ADR were skin and accessory injuries (68 cases, 43.04% ), Followed by digestive system damage (34,21.52%). Conclusion The monitoring and reporting of ADR is conducive to mastering more drug information, regulating the rational use of drugs, controlling the risk of adverse reactions, and ensuring the safety of patients.