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壳聚糖是甲壳素的脱乙酰化产物,由D—氨基钙葡萄糖与少量N—乙酰氨基萄葡糖通过β—1,4键连接的直链分子。具有重要的医用价值,如降低血液胆固醇水平、促进伤口愈合、激活免疫系统及抗肿瘤作用等。通常,壳聚糖的制备需要甲壳素在50％W/V的强碱溶液中煮沸3小时以上。本文介绍的热-机-化处理过程可降低碱溶液浓度至10％,促进甲壳素/壳聚糖的转变过程,使反应时间减少到1～5分钟内,并可控制产物的脱乙酰化程度。主要步骤
Chitosan is a deacetylated product of chitin, a linear molecule consisting of D-glucosamine and a small amount of N-acetylglucosamine linked by β-1,4 linkages. Has important medical value, such as reducing blood cholesterol levels, promote wound healing, activate the immune system and anti-tumor effect. In general, the preparation of chitosan requires that chitin be boiled for more than 3 hours in a 50% w / v strong alkaline solution. This paper describes the heat - machine - treatment process can reduce the concentration of alkali solution to 10%, promote chitin / chitosan transformation process, the reaction time is reduced to 1 to 5 minutes, and can control the degree of product deacetylation . The main steps