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目的:探讨不同子宫颈成熟条件对米索前列醇(Misoprostol)足月妊娠引产的效果及不良反应的影响。方法:全面检索1995年1月～2002年3月有关米索前列醇引产的文献,筛选合格文献,提取数据资料,应用SAS中的meta分析软件包对各研究进行一致性检验和采用相应数学模型进行数据合并。结果:筛选到合格的文献9篇。数据合并得出引产成功率在高子宫颈评分中米索前列醇组为96.0%,催产素组为87.7%,两组标准率差为8.9%(95%可信区间0.2%,17.5%),P<0.05;低子宫颈评分中的引产成功率两组分别为92.4%和53.6%,标准率差为37.3%(95%可信区间23.2%,51.5%),P=2.3×10-7。米索前列醇组宫缩过强、剖宫产、新生儿窒息的平均发生率在高子宫颈评分组高于低子宫颈评分组。结论:米索前列醇在足月妊娠引产中效果好,但更适合应用于低子宫颈评分的孕妇。
Objective: To investigate the effect of different cervical ripening conditions on the effect and side effects of Misoprostol on term pregnancy induced labor. Methods: A comprehensive search of literature about misoprostol induction of labor from January 1995 to March 2002 was conducted. The qualified literature was screened and the data were extracted. The consistency of each study was tested using SAS meta-analysis software package and the corresponding mathematical models Data consolidation. Results: Nine qualified articles were screened. The combined data showed that the success rate of induction of labor was 96.0% in the high cervix score, 87.7% in the oxytocin group, and 8.9% in the two groups (95% confidence interval 0.2%, 17.5%), P <0.05. The success rate of induction of labor in the low cervical score was 92.4% and 53.6% in the two groups, with a standard deviation of 37.3% (95% confidence interval 23.2%, 51.5%), P = 2.3 × 10-7. In the misoprostol group, the average rate of cesarean section, cesarean section, and neonatal asphyxia was higher in the high cervical score group than in the low cervical score group. CONCLUSIONS: Misoprostol is effective in induction of labor during term pregnancy but is more suitable for pregnant women with low cervical score.