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目的：探讨抗血小板活性药物对儿童肾病综合征，尤其是并发高凝状态时的临床疗效。方法将2011年4月~2013年4月将86例儿童肾病综合征，随机分为试验组与对照组。试验组在常规治疗的基础上加入小剂量抗血小板活性药物阿司匹林，对照组予利尿、维生E、抗炎等常规治疗，治疗前后观察尿蛋白及血浆白蛋白水平。结果两组患者治疗后2w尿蛋白阳性例数比较无显著性差异(P>0.05)，治疗后1个月与对照组比较，尿蛋白阳性例数明显减少(P<0.05)。两组患者治疗2w后血浆白蛋白值均有升高，治疗组的血浆白蛋白恢复正常，两组数值比较有显著性差异(P<0.05）。结论血小板活性与肾病时高凝状态间的关系是影响其预后的因素之一，在常规治疗儿童肾病综合征的基础上加入少剂量抗血小板活性的药物能提高临床疗效，可有效的降低蛋白尿的排泄。“,”Objective: To investigate the clinical ef icacy of antiplatelet drugs on children with nephrotic syndrome. Methods: in 2011 April to 2013 April 86 cases of nephrotic syndrome in children, were randomly divided into experimental group and control group. The test group with smal dose aspirin antiplatelet drugs on the basis of conventional therapy, the control group conventional treatment. Results:the treatment group's recent remission rate, urine protein negative than those in the control group, the incidence rate of adverse reaction was lower than the control group. Conclusion: platelet activation and the relationship between hypercoagulability in nephrotic, is one of the factors af ecting the prognosis, based on routine treatment in children with nephrotic syndrome drug adding less dose antiplatelet activity can improve the clinical ef icacy. The use of smal dose of antiplatelet drug, has a good ef ect on reducing proteinuria.