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作者报告一例成人用丙戊酸钠引起肝细胞中毒性损害。活组织经光学显微镜和电子显微镜得到证实。女,37岁,因发热和腹部不适于1981年5月住院。同年四月,她突然意识丧失被送到本院神经外科,诊为珠网膜下腔出血。当时以颈部切口,珠网膜下腔引流,吸入麻醉药。手术当天开始,每天给丙戍酸钠1.2克。第一次手术后9天行颅成形术。在用丙戊酸钠的第20天,体温升高在37.0至38.0℃之间一周,此后体温高达40℃,持续了3天来院
The authors report a case of adults with sodium valproate cause hepatotoxic injury. Live tissue was confirmed by optical and electron microscopy. Female, 37 years old, hospitalized for fever and abdominal discomfort in May 1981. In the same year in April, she suddenly lost consciousness was sent to our hospital neurosurgery, diagnosed as sub-subdural hemorrhage. At that time to the neck incision, subretinal drainage, inhalation of anesthetics. On the day of surgery, 1.2 grams of sodium palmitate was given daily. 9 days after the first surgery cranioplasty. On day 20 with sodium valproate, body temperature increased between 37.0 and 38.0 ° C for one week, after which body temperature reached 40 ° C for 3 days