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某些磺酸酯(ArSO_2OR)可作为Friedel-Crafts反应的烃化剂,R多为简单的烃基。七十年代后期,日本公开特许先后报道了以O-对甲苯磺酰乳酸(Ⅰ)或其酯(Ⅰ′)一步合成非甾消炎镇痛解热药布洛芬或萘普生。RH+TsO-CHCOOH(CH_3)→R-CHCOOH(CH_3)
Some sulfonate esters (ArSO_2OR) can be used as Friedel-Crafts reaction of the hydrocarbon agent, R mostly simple hydrocarbon. In the late seventies, Japanese Laid-Open Patent reported the one-step synthesis of non-steroidal anti-inflammatory analgesic antipyretics ibuprofen or naproxen with O-p-toluenesulfonyllactate (I) or its ester (I ’). RH + TsO-CHCOOH (CH_3) → R-CHCOOH (CH_3)