【摘 要】
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Target of rapamycin (TOR) is an evolutionary conserved serine/threonine protein kinase found in yeast,plants,and animals.TOR plays a central role in sensing nut
【机 构】
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Max-Planck-Institute of Molecular Plant Physiology,Am Muehlenberg 1, 14476 Potsdam, Germany
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Target of rapamycin (TOR) is an evolutionary conserved serine/threonine protein kinase found in yeast,plants,and animals.TOR plays a central role in sensing nutrients and energy status,growth factors,and other environmental signals,and integrates these cues to synchronize cell growth-related processes (Laplante and Sabatini,2012).In yeast and animal cells,TOR acts as the catalytic component in two structurally and functionally distinct protein complexes termed TORC (TOR complex) 1 and TORC2.TOR seems to be localized specifically to the endomembrane system and the nucleus with a certain mobility,depending on the environmental conditions (Laplante and Sabatini,2012).
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