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风湿性关节炎是一种常见病、多发病。日前,基层医疗单位普遍应用治疗关节炎的药物是:乙酰水杨酸加皮质激素。在治疗过程中,由于给药时间和给药次数的不同,治疗效果和毒副作用也大有差异。早晨给药,尿中达最大排泄率所需时间最长,水杨酸类药物由尿中排出的时间(即在尿中能测得药物的时间)也最长;相反,如在晚间给药,药物由尿中排泄最快,排泄时间也最短。因此,早晨给药后,不能很快达到血浓度的峰值,而前一天晚间给药,又因排泄快而致早晨的血药浓度偏低。关节炎患者的疼痛恰恰是在凌晨多发,若将每日总量均分的服药方法,
Rheumatoid arthritis is a common disease, frequently-occurring disease. Recently, the primary medical units commonly used drugs for the treatment of arthritis are: acetylsalicylic acid plus corticosteroids. In the course of treatment, due to the different administration times and the number of dosing, the curative effect and side effects are also greatly different. It takes the longest to reach the maximum excretion rate in the urine in the morning, and the salicylic acid is discharged from the urine (ie, the time when the medicine can be measured in the urine) is longest; on the contrary, if it is administered in the evening , The fastest excretion of drugs by the urine, excretion time is also the shortest. Therefore, the morning after administration, can not quickly reach the peak blood concentration, and the previous night’s administration, and due to excretion quickly caused by morning plasma concentration is low. The pain of arthritis patients is precisely in the early morning, if the daily total amount of medication,