论文部分内容阅读
目的 研究注射用潘托拉唑钠对大鼠和小鼠急性胃溃疡动物模型的影响.方法 采用小鼠水浸应激性胃溃疡模型,大鼠幽门结扎胃溃疡模型,同时观察幽门结扎大鼠胃酸分泌情况.结果 静脉注射潘托拉唑钠5,10,20mg·kg~(-1),对小鼠水浸应激性胃溃疡具有减少溃疡发生的作用,4,8,16mg·kg~(-1)对幽门结扎大鼠的胃溃疡面积具有明显的缩小作用,两者均呈剂量依赖性.对胃酸的分泌具有较强的抑制作用,对胃蛋白酶活性也具有抑制作用.上述结果与同剂量的奥美拉唑比较作用相似.结论 注射用潘托拉唑钠对大鼠小鼠实验性急性胃溃疡具有明显的保护作用.
Objective To study the effect of pantoprazole sodium for injection on the animal model of acute gastric ulcer in rats and mice.Methods The mice model of gastric ulcer induced by water immersion was used in this study.The model of gastric ulcer was ligated in pylorus in rats and the rats in pylorus ligation Gastric acid secretion.Results Intravenous injection of pantoprazole sodium 5,10,20 mg · kg ~ (-1) had the effect of reducing the occurrence of ulcer in water immersion stress gastric ulcer in mice, 4,8,16mg · kg ~ (-1) (-1) significantly reduced gastric ulcer area in rats with pylorus ligation, both of which were dose-dependent, had strong inhibitory effect on gastric acid secretion and also inhibited gastric pepsin activity.The above results The same dose of omeprazole compared with similar effects.Conclusion Injection of pantoprazole sodium in rats with experimental acute gastric ulcer has a significant protective effect.