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下丘脑ＧｎＲＨ脉冲发生器调节ＧｎＲＨ间歇地释放到垂体门脉循环中，进而调节ＬＨ的脉冲式分泌。各种内外因素可修正ＧｎＲＨ脉冲发生器的活动，后者改变促性腺激素的分泌模式，并最终影响生殖功能。用多单位活动（ＭＵＡ）记录技术从切除卵巢的山羊和发情周期母山羊上成功地记录了与ＬＨ脉冲式分泌有关的神经元活动的特征性增加。ＭＵＡ群射呈周期性增加，并与ＬＨ脉冲保持良好关系，ＭＵＡ群射是ＧｎＲＨ脉冲发生器活动的结果。本文将综述长期记录ＧｎＲＨ脉冲发生器活动的方法及其研究应用
The hypothalamic GnRH pulsator regulates the release of GnRH intermittently into the pituitary portal circulation, which in turn modulates the pulsatile secretion of LH. A variety of internal and external factors can correct GnRH pulse generator activity, which changes the gonadotropin secretion patterns and ultimately affect reproductive function. Multi-unit activity (MUA) recording techniques were used to record a characteristic increase in neuronal activity associated with LH pulsatile secretion from ovariectomized goats and estrous cycle goats. The MUA burst increased periodically and remained well correlated with the LH pulse, which was the result of GnRH pulser activity. This article reviews the long-term record of GnRH pulser activities and their applications