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十八甲基炔诺酮(norgestrel,NG)首先由Smith成功的完成了人工合成,并证明是一个具有较强孕激素活性和较弱雄激素活性的十九去甲睾丸酮衍生物。近二十年来,通过口服,阴道环,宫内节育器,皮下埋植和肌肉注射等渠道广泛地应用于临床。证实对下丘脑-垂体-卵巢轴具有抑制作用,且毒性很小。因此对NG的药物代谢动力学的认识就显得非常重要,本文对此作一综述。吸收与血药浓度口服口服是NG最常用的给药方式,吸收迅速,血浆浓度一般在给药后30分钟至2小时达峰值。Alvarez的结果证实口服
Norgestrel (NG) was first successfully synthesized by Smith and proved to be a non-noreprenate testosterone derivative with strong progestin activity and weaker androgen activity. Nearly two decades, through the oral, vaginal ring, intrauterine device, subcutaneous implantation and intramuscular injection channels widely used in clinical. Confirmed the hypothalamus - pituitary - ovarian axis inhibition, and toxicity is very small. Therefore, understanding of the pharmacokinetics of NG becomes very important, this article reviews it. Absorption and plasma concentrations Oral oral administration is the most commonly used mode of administration of NG, rapidly absorbed and plasma concentrations typically reach peak values of 30 minutes to 2 hours after administration. Alvarez’s results confirm oral