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Teicoplanin属于万古霉素类结构的新糖肽抗生素,有良好的抗菌活性和药代动力学特性,特别是有较好的细胞透过性。在微生物被巨噬细胞吞噬,部分尚可存活,甚至可免受血清和细胞外抗生素的杀伤,导致感染的慢性化或迁延性。本文探讨了Teicoplanin在人体巨噬细胞中的透过性和巨噬细胞吞噬功能之间的相互作用。药物透过能力的观察,应用~(14)C标记Teicoplanin,取浓度为20、10、1和0.5mg/L,加入培养基中和吞噬细胞一起培养30、60、90、120、180min和24小时,然后测定
Teicoplanin vancomycin belongs to the class of new glycopeptide antibiotics, has good antibacterial activity and pharmacokinetic properties, especially with better cell permeability. Phagocytosis of microorganisms by macrophages, some still survive, and even from the serum and extracellular antibiotics kill, leading to chronic or persistent infection. This article explores the interaction between Teicoplanin permeability in human macrophages and macrophage phagocytosis. Drug penetration through the observation, the application of ~ (14) C-labeled Teicoplanin, take the concentration of 20,10,1 and 0.5mg / L, added to the medium and phagocytic cells were cultured with 30,60,90,120,180min and 24 Hour, then measure