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转化生长因子 β (TGF β)是一类分泌型多肽信号分子 ,在生物体发育及组织修复过程中发挥重要的调节作用。SMAD家族是一类新发现的TGF β信号的细胞质内介导者 ,它们可将TGF β信号直接从细胞膜转入细胞核内 ,并激活靶基因的转录。其中SMAD3和SMAD2作为受体激活的SMADs介导TGF βs和激活素 (activins)的细胞内信号。Smad 3基因敲除小鼠 (Smad 3ex8/ex8)可以存活至成年 ,其伤口愈合过程较正常对照鼠明显加快 ,并具有重上皮化加速和局部炎症反应减弱等特点。SMAD3在组织修复过程中的特殊作用途径可能成为治疗慢性难愈合伤口的靶点。
Transforming growth factor β (TGFβ) is a type of secreted polypeptide signaling molecule that plays an important regulatory role in the development of organism and tissue repair. The SMAD family is a class of cytoplasmic mediators of newly discovered TGFβ signaling that translocates TGFβ signaling directly from the cell membrane into the nucleus and activates transcription of target genes. Among them, SMAD3 and SMAD2, as receptor-activated SMADs, mediate intracellular signals of TGFβs and activins. Smad 3 knockout mice (Smad 3ex8 / ex8) survived to adulthood and their wound healing was markedly accelerated compared to normal control mice with accelerated re-epithelization and a diminished local inflammatory response. SMAD3 in the process of tissue repair in a special way may be the treatment of chronic wounds difficult to target.