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目的:观察黄精赞育方加味联合前列通瘀胶囊治疗不育患者精浆抗精子抗体异常的临床效果。方法:将263例患者随机分为2组,中药联合组148例采用黄精赞育方加味联合前列通瘀胶囊治疗,对照组115例采用强的松小剂量持续疗法,疗程均为3月。观察2组治疗前后精浆抗精子抗体、精子密度及活动力的改变。结果:精浆抗精子抗体转阴疗效:有效率中药联合组为91.21%,对照组为69.57%,2组比较,差异有非常显著性学意义(P<0.01)。治疗后中药联合组精子密度、活动力较治疗前显著改善(P<0.05);与对照组比较,差异也有显著性意义(P<0.05)。对照组精子密度、活动力治疗前后变化不大(P>0.05)。不良反应率中药联合组为2.70%,对照组为15.65%,2组比较,差异有显著性意义(P<0.05)。结论:黄精赞育方加味联合前列通瘀胶囊治疗不育患者精浆抗精子抗体异常临床效果显著,副作用小。
Objective: To observe the clinical effect of Huangjingzan Prescription plus Qianlietongtongyu Capsule in the treatment of infertility patients with antisperm antibody abnormalities. Methods: A total of 263 patients were randomly divided into two groups. 148 cases in the combination group were treated with Huangjingzan Prescription plus Qianlietongtong Capsule, while in the control group, 115 cases were treated with prednisone and low dose continuous treatment for three months. The changes of sperm anti-sperm antibody, sperm density and motility before and after treatment were observed in two groups. Results: Seminal plasma anti-sperm antibody negative effect: the effective rate of Chinese medicine combined group was 91.21% and that of control group was 69.57%. There was significant difference between the two groups (P <0.01). After treatment, the sperm density and motility of Chinese medicine combined group were significantly improved (P <0.05) compared with those before treatment; the difference was also significant (P <0.05) compared with the control group. The control group sperm density, motility change little before and after treatment (P> 0.05). The rate of adverse reactions was 2.70% in the combination group and 15.65% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The combination of Huangjingzan Prescription and Qianlietongtongyu Capsule in the treatment of infertility patients has significant clinical effect on the abnormal sperm anti-sperm antibody with small side effects.