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Rho激酶(ROCK)是Rho的主要效应底物,含两种异构体ROCKI及ROCKII,属于丝/苏氨酸蛋白激酶。ROCK的主要生物学作用是灭活肌球蛋白轻链磷酸酶,使血管痉挛,并可促进炎性因子分泌、参加炎性因子损害过程、促进细胞凋亡、使神经突触崩解等,Rho激酶在多种病理因素如外伤、炎症、缺血、肿瘤、变性所导致的原发性或继发性神经损伤中起主要作用。ROCK抑制剂通过其扩张血管,改善循环,神经保护,抑制白细胞浸润、吞噬功能,减轻炎性损害,促进神经再生和神经生长,在治疗原发性或继发性神经损伤疾病中有着广泛的应用前景。
Rho kinase (ROCK) is the main effect of Rho substrate, containing two isomers ROCKI and ROCKII, belonging to the silk / threonine protein kinase. ROCK’s main biological role is to inactivate myosin light chain phosphatase, vasospasm, and can promote the secretion of inflammatory cytokines, inflammatory factors involved in the process of damage, promote apoptosis, disintegration of neuronal synapses, etc., Rho Kinases play a major role in primary or secondary neurological damage resulting from a variety of pathological factors such as trauma, inflammation, ischemia, tumors, degeneration. ROCK inhibitors are widely used in the treatment of primary or secondary neurological injury by dilating blood vessels, improving circulation, neuroprotection, inhibiting leukocyte infiltration, phagocytosis, reducing inflammatory damage, promoting nerve regeneration and nerve growth prospect.