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目的：：优选脱甲氧基姜黄素纳米脂质载体( CurⅡ-NLC)的最佳处方工艺。方法：以包封率为主要考察指标,采用单因素考察和正交试验法研究制备工艺中影响纳米粒质量的主要因素,筛选出较理想的处方和工艺。结果：优选的最佳处方工艺为：药脂比为1∶40,液态脂质占总脂质的比例为10%,卵磷脂的用量为2%,表面活性剂用量为4%。优化工艺所制备的纳米粒为球形或类球形实体,粒径在110nm左右,PDI为0.199,粒径分布均匀。结论：由正交试验法优选处方工艺稳定可行,为脱甲氧基姜黄素进一步研究提供参考依据。“,”Objective:To screen the optimal formula and technology of demethoxycurcumin nano-structured lipid carriers. Meth-ods:The encapsulation efficiency as the main investigation index, the single factor exploration and orthogonal design were used to study the main factors affecting the quality of the nanoparticles. The optimal formula and technology were obtained. Results:The optimized parameters were as follows:the ratio of drug to lipid materials was 1 ∶40, the ratio of liquid lipid to total lipid materials was 10%, the amount of surfactants was 4% and the amount of lecithin was 2%. The prepared nanoparticles were spheric and regular. The size dis-tribution of the nanoparticles was narrow with the average particle size of 110nm and PDI of 0. 199. Conclusion:The optimized formula and technology of demethoxycurcumin nano-structured lipid carriers are stable and practicable,which provide reference for the further research of demethoxycurcumin.